Effective drug delivery to the tumor site with TERP
TERP is our next generation platform technology
- Active transportation of diagnostic and therapeutic agents into tumor cells and across the intact Blood-Brain-Barrier (BBB) to reach inoperable brain tumor tissue
- A high degree of flexibility to accommodate various payloads and antibody/receptor-guided targeting to specific tumor types
Overcoming tumor hypoxia with T-MX
T-MX is our TERP-enabled, first-in-class therapeutic agent designed to overcome tumor hypoxia. T-MX re-oxygenates hypoxic cancer cells, which in turn, boosts immunogenic cell death and strikingly increases the therapeutic efficacy of radio, chemo, and immunotherapy in multiple cancer models, agnostic to tumor genotype and histology.
T-MX has the potential to provide greater therapeutic efficacy and longer patient survival, offering healthcare professionals a potentially curative approach across a broad range of cancers, patient populations, and treatment options.
T-MX has the potential to provide greater therapeutic efficacy and longer patient survival, offering healthcare professionals a potentially curative approach across a broad range of cancers, patient populations, and treatment options.
T-MX provides differentiation and superiority compared with currently available compounds
- Safe and effective potentiation: 5-fold improvement over standard radiation and immunotherapies.
- Broad applicability across multiple tumor types regardless of underlying genetic factors
- Directly overcomes tumor hypoxia by local oxygen generation.
- Restores T-Cells' tumor-killing function and boosts anti-tumor immunity
- Enhanced uptake and retention in tumors.
- Enables MR imaging of target tumor engagement.
- Robust, streamlined, and scalable manufacturing process.
Preclinical Data
Target Engagement Determination using MRI
Manganese ions in T-MX are paramagnetic and detectable by MRI with high sensitivity. This enables:
- Quantification of drug accumulation in solid tumors.
- Accurate image-based biodistribution analysis.
- Precise MR-guided RT therapy, in cases where systemic therapies and RT are prescribed together.
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